1.Department of Pathology Centro di Riferimento Oncologico Aviano (CRO), Istituto Nazionale Tumori, IRCCS, Aviano, Italy; acarbone@cro.it (AC); Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy; annunziata.gloghini@istitutotumori.mi.it (AG)2.Department of Pathology Centro di Riferimento Oncologico Aviano (CRO), Istituto Nazionale Tumori, IRCCS, Aviano, Italy; acarbone@cro.it (AC); Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy; annunziata.gloghini@istitutotumori.mi.it (AG)
This CARD addresses the following questions: 1) how should in situ follicular neoplasia be defined and diagnosed? and 2) how should people/patients with in situ follicular neoplasia be managed?
Without overt lymphoma
Associated with overt lymphoma
With overt follicular lymphoma (FL)
Early infiltration by synchronous FL
or preceding FL by years
With lymphomas other than FL
splenic marginal zone lymphoma
Classic Hodgkin Lymphoma
Diffuse Large B-Cell Lymphoma
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Lymphoplasmacytic lymphoma
Peripheral T-cell lymphoma, unspecified
Associated with non lymphoid malignancies
Colorectal carcinoma
Breast carcinoma
Melanoma
Lung carcinoma
Other (sporadic reports)
Architecture
Intact
Follicle size
Normal
Distribution of involved follicles
Widely scattered
Follicular cuff
Follicular edge
Sharp
Expression of BCL2
Positive, very B
Expression of CD10
Expression of CD20
Positive
Expression of BCL6
Expression of CD3
Negative
Follicular involvement
Usually limited to germinal center
Stromal microenvironment of the mantle
Annunziata Gloghini ; Antonino Carbone
In situ follicular neoplasia
Atlas Genet Cytogenet Oncol Haematol. 2016-08-01
Online version: http://atlasgeneticsoncology.org/haematological/1757/in-situ-follicular-neoplasia