dic(1;15)(p11;p11)

2007-08-01 Jean-Loup Huret Affiliation

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Myeloid malignancies

Phenotype stem cell origin

Myloproliferative diseases (MPD) in 3 of 10 available cases (polycytemia vera (PV) in all 3 cases), myelodysplastic syndromes (MDS) in 6 cases (mainly refractory anaemia (RA): 5 cases; RARS in one case), acute myeloid leukaemia (AML) of M7 type in one case.

Epidemiology

At least 10 cases; balanced sex ratio (5M/5F); median age was 47 yrs (range 15-81)

Kaplan-Meier on 10 cases of dic(1;15) from the literature; survivals (in months) were: 4, 14, 23+, 24+, 27, 40+, 93+, 96, 235.

Prognosis

About 60% of cases were still alive 2 to 8 yrs after diagnosis (see figure1), but with a too short follow up of a too small cohort, no real conclusions can be drawn. It is likely that the prognosis depend more on the haematological diagnosis (AML versus MDS, vs MPD).

Genes Involved and Proteins

Note

Genes involved are unknown; the translocation breakpoints are likely to be in heterochromatic regions

Bibliography

Pubmed ID	Last Year	Title	Authors
12091356	2002	Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH).	Dastugue N et al
2340487	1990	Cytogenetic analysis of 54 cases of myelodysplastic syndrome.	Jotterand-Bellomo M et al
2713819	1989	A dysmorphic child with myelodysplasia characterized by a duplication of 1q and multiple duplications of 3q.	Mascarello JT et al
3954964	1986	An identical translocation between chromosome 1 and 15 in two patients with myelodysplastic syndromes.	Mecucci C et al
8630988	1996	Dicentric (1;15) in myeloid disorders.	Michaux L et al
3706291	1986	Trisomy 1q in polycythemia vera and its relation to disease transition.	Swolin B et al
1251221	1976	Cytogenetic studies in polycythemia vera.	Wurster-Hill D et al

Summary

dic(1;15)(p11;p11) G- banding - Courtesy Catherine Roche-Lestienne, Olivier Theisen, Jean-Luc Lai.

Citation

Jean-Loup Huret

dic(1;15)(p11;p11)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/haematological/1159/dic(1;15)(p11;p11)