12p rearrangements in CLL

2005-07-01   Kavita S Reddy 

1.Genzyme Genetics, 1054 Town, Country Road, Orange, CA 92868, USA

Clinics and Pathology

Disease

Chronic lymphoproliferative leukemia (CLL)

Epidemiology

A 12p rearrangement is observed in about 1.4% CLL cases usually as part of a complex karyotype with multiple abnormalities, but about 7.7% of these are apparently sole cytogenetic abnormality.

Prognosis

12p rearrangements in CLL probably are early chromosome defects that are not associated with the classical DNA gains and losses known to be present in the majority of CLL. An atypical morphology and immunophenotype may be present in cases with 12p rearrangements; and frequently there is disease progression.
Transformation of CLL to PLL has been observed in cases with a 12p abnormality.

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Citation

Kavita S Reddy

12p rearrangements in CLL

Atlas Genet Cytogenet Oncol Haematol. 2005-07-01

Online version: http://atlasgeneticsoncology.org/haematological/2023/12p-rearrangements-in-cll