t(14;19)(q11;q13) TRA/NECTIN2

2019-09-01   Jean Loup Huret 

1.jean-loup.huret@atlasgeneticsoncology.org

Abstract

Review on t(14;19)(q11;q13), with data on clinics, and the genes involved.

Clinics and Pathology

Disease

T-cell lymphomas

Epidemiology

Four cases available to date: three peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) (two male patients aged 20 and 63 yrs and one female patient aged 63 yrs), and one angioimmunoblastic T-cell lymphoma (Lepretre et al., 2000; Almire et al., 2007; Shin et al., 212).

Other features

Recently, the cell line T8ML-1 with t(14;19) TRA/NECTIN2 was established from a 64-year old female patient diagnosed with fatal PTCL-NOS (Ehrentraut et al., 2017).

Genes Involved and Proteins

Gene name
TRA (T cell Receptor Alpha)
Location
14q11.2
Gene name
NECTIN2 (nectin cell adhesion molecule 2)
Location
19q13.32
Note
NECTIN2 is also called PVRL2 (poliovirus receptor-related 2).
Protein description
NECTIN2 is a cell membrane protein involved in immune checkpoint, part of the TIGIT-PVR/PVRL2 axis. NECTIN2 is composed of a signal peptide (amino acids (aa) 1-31), an extracellular domain (aa 32-360), a transmembrane domain (aa 361-381), and a cytoplasmic domain (aa 382-538). NECTIN2 also interacts with PVRIG CD226, CD96 to stimulate or inhibit lymphocyte cell signaling (Stamm et al., 2018; Whelan et al., 2019).

Result of the Chromosomal Anomaly

Note

On chromosome 19, there was a cluster of breakpoints in the NECTIN2 gene region, 130 kb downstream of BCL3. The breakpoints on chromosome 14 were located in theTRAJ region (Almire et al., 2007).

Oncogenesis

NECTIN2 was highly expressed in the t(14;19)(q11;q13)-positive tumors.

Bibliography

Pubmed IDLast YearTitleAuthors
176961932007PVRL2 is translocated to the TRA@ locus in t(14;19)(q11;q13)-positive peripheral T-cell lymphomas.Almire C et al
286593342017Peripheral T-cell lymphoma cell line T8ML-1 highlights conspicuous targeting of PVRL2 by t(14;19)(q11.2;q13.3).Ehrentraut S et al
221228002012A rare case of Lennert's type peripheral T-cell lymphoma with t(14;19)(q11.2;q13.3).Shin SY et al
301320622018Interaction of PVR/PVRL2 with TIGIT/DNAM-1 as a novel immune checkpoint axis and therapeutic target in cancer.Stamm H et al
306590542019PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8(+) T-cell Function.Whelan S et al

Summary

Fusion gene

TRA/NECTIN2

Citation

Jean Loup Huret

t(14;19)(q11;q13) TRA/NECTIN2

Atlas Genet Cytogenet Oncol Haematol. 2019-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1513/t(14;19)(q11;q13)-tra-nectin2