CAGE1 (cancer-associated gene-1)

2003-07-01   Jean-Loup Huret , Sylvie Senon 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
CAGE1
LOCATION
6p24.3
LOCUSID
285782
ALIAS
CT3,CT95,CTAG3,bA69L16.7
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

spans 63 kb; 11 exons; ORF: 1920 bp

Proteins

Expression

testis-restricted in normal tissues; wide/high expression in various cancer tissues (lung, cervix, stomach) CAG1 is a probable member of the cancer/testis antigen family

Localisation

mainly nuclear

Function

may be involved in signaling pathway

Homology

with monkey genes with testis specific expression

Mutations

Somatic

may be associated with tumor progression .

Implicated in

Bibliography

Pubmed IDLast YearTitleAuthors
125314762003Identification and characterization of a novel cancer/testis antigen gene CAGE-1.Park S et al

Other Information

Locus ID:

NCBI: 285782
MIM: 608304
HGNC: 21622
Ensembl: ENSG00000164304

Variants:

dbSNP: 285782
ClinVar: 285782
TCGA: ENSG00000164304
COSMIC: CAGE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164304ENST00000296742Q8TC20
ENSG00000164304ENST00000338150Q8TC20
ENSG00000164304ENST00000379918E7EUJ7
ENSG00000164304ENST00000442019D6R9A7
ENSG00000164304ENST00000458291Q8TC20
ENSG00000164304ENST00000502583Q8TC20
ENSG00000164304ENST00000512086Q8TC20
ENSG00000164304ENST00000512691D6RCC6

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
169644032006Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.14
177862882007High frequency of promoter methylation of the 14-3-3 sigma and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder.6
125314762003Identification and characterization of a novel cancer/testis antigen gene CAGE-1.0
171142842006Characterization of a cancer/testis (CT) antigen gene family capable of eliciting humoral response in cancer patients.0
241745342013miR-200b and cancer/testis antigen CAGE form a feedback loop to regulate the invasion and tumorigenic and angiogenic responses of a cancer cell line to microtubule-targeting drugs.0

Citation

Jean-Loup Huret ; Sylvie Senon

CAGE1 (cancer-associated gene-1)

Atlas Genet Cytogenet Oncol Haematol. 2003-07-01

Online version: http://atlasgeneticsoncology.org/gene/475/cage1