EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2)

2000-07-01   Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
3q27.3
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
BM-010,DDX2B,EIF4A,EIF4F,eIF-4A-II,eIF4A-II
FUSION GENES

DNA/RNA

Transcription

1.9 kb mRNA; 1223 bp coding sequence

Proteins

Description

407 amino acids; 4.6 kDa; NH2-term, ATP binding site, DEAD box, COOH-term

Expression

wide; also expressed in the embryo

Function

ADP/ATP binding; RNA helicase; binds mRNA to the ribosome: role in initiation of protein synthesis; also -binds single strand DNA

Homology

DEAD box proteins, in particular other EIF4A

Implicated in

Disease
non-Hodgkin lymphoma
Prognosis
yet unknown (only 1case available)
Hybrid gene
5 EIF4A2 - 3 BCL6; EIF4A2 fuses with the second exon of BCL6
Fusion protein
no fusion protein, but promoter exchange
Oncogenesis
BCL6 is a transcription repressor; it is supposed that substitution of the promoter of BCL6 may be responsible for BCL6 deregulation

Bibliography

Pubmed IDLast YearTitleAuthors
105236221999Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII.Li Q et al
94853651998The DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes.Lorsch JR et al
85217301995Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2.Sudo K et al
106375101999Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples.Yoshida S et al

Other Information

Locus ID:

NCBI: 1974
MIM: 601102
HGNC: 3284
Ensembl: ENSG00000156976

Variants:

dbSNP: 1974
ClinVar: 1974
TCGA: ENSG00000156976
COSMIC: EIF4A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156976ENST00000323963Q14240
ENSG00000156976ENST00000425053E7EQG2
ENSG00000156976ENST00000426808E9PBH4
ENSG00000156976ENST00000429589E9PBH4
ENSG00000156976ENST00000440191Q14240
ENSG00000156976ENST00000441007C9JUF0
ENSG00000156976ENST00000443963F8WE11
ENSG00000156976ENST00000445596E7EMV8
ENSG00000156976ENST00000498746J3KSN7

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
eIF4F complexKEGGhsa_M00428
eIF4F complexKEGGM00428
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
214277652011mRNA helicases: the tacticians of translational control.146
182501592008Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells.60
185939342008c-Myc and eIF4F are components of a feedforward loop that links transcription and translation.54
225893332012A cellular response linking eIF4AI activity to eIF4AII transcription.40
190343802009Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.36
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
266146652015Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence.14
119226172002Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro.12
271606822016Sumoylation of eIF4A2 affects stress granule formation.9
165675442006EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families.7

Citation

Jean-Loup Huret

EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2)

Atlas Genet Cytogenet Oncol Haematol. 2000-07-01

Online version: http://atlasgeneticsoncology.org/gene/262/eif4a2