AADAT (aminoadipate aminotransferase)

2014-11-01  

Identity

HGNC
LOCATION
4q33
LOCUSID
ALIAS
KAT2,KATII,KYAT2
FUSION GENES

Other Information

Locus ID:

NCBI: 51166
MIM: 611754
HGNC: 17929
Ensembl: ENSG00000109576

Variants:

dbSNP: 51166
ClinVar: 51166
TCGA: ENSG00000109576
COSMIC: AADAT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109576ENST00000337664Q8N5Z0
ENSG00000109576ENST00000337664Q4W5N8
ENSG00000109576ENST00000353187Q8N5Z0
ENSG00000109576ENST00000353187Q4W5N8
ENSG00000109576ENST00000502392D6RC56
ENSG00000109576ENST00000507375D6RFY7
ENSG00000109576ENST00000509167Q8N5Z0
ENSG00000109576ENST00000510340D6REB9
ENSG00000109576ENST00000515480Q8N5Z0
ENSG00000109576ENST00000515480Q4W5N8

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Lysine biosynthesisKEGGko00300
Lysine degradationKEGGko00310
Tryptophan metabolismKEGGko00380
Lysine biosynthesisKEGGhsa00300
Lysine degradationKEGGhsa00310
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGhsa_M00032
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGM00032
2-Oxocarboxylic acid metabolismKEGGhsa01210
2-Oxocarboxylic acid metabolismKEGGko01210
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Lysine catabolismREACTOMER-HSA-71064
Tryptophan catabolismREACTOMER-HSA-71240
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180569952008Crystal structure of human kynurenine aminotransferase II.24
217127762011Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2,3-dioxygenase and lowered kynurenine aminotransferase activity.22
180569962008Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia.18
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
121269302002Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).10
214737612011Association of kynurenine aminotransferase II gene C401T polymorphism with immune response in patients with meningitis.9
303670592018Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.8
241402522013Exercise affects symptom severity but not biological measures in depression and somatization - results on IL-6, neopterin, tryptophan, kynurenine and 5-HIAA.7
267737452016Expression, purification and crystallization of human kynurenine aminotransferase 2 exploiting a highly optimized codon set.5
287064362017The presence of kynurenine aminotransferases in the human cornea: Evidence from bioinformatics analysis of gene expression and immunohistochemical staining.2

Citation

Dessen P

AADAT (aminoadipate aminotransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60013/aadat