ABI2 (abl interactor 2)

2003-02-01  

Identity

HGNC
LOCATION
2q33.2
LOCUSID
ALIAS
ABI-2,ABI2B,AIP-1,AIP1,AblBP3,SSH3BP2,argBP1,argBPIA,argBPIB
FUSION GENES

Other Information

Locus ID:

NCBI: 10152
MIM: 606442
HGNC: 24011
Ensembl: ENSG00000138443

Variants:

dbSNP: 10152
ClinVar: 10152
TCGA: ENSG00000138443
COSMIC: ABI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138443ENST00000261016B7Z836
ENSG00000138443ENST00000261017Q9NYB9
ENSG00000138443ENST00000261018F8WAL6
ENSG00000138443ENST00000295851F8WAL6
ENSG00000138443ENST00000413635F8WAU3
ENSG00000138443ENST00000416001F8WBL5
ENSG00000138443ENST00000417864E7EP65
ENSG00000138443ENST00000422511E7EW77
ENSG00000138443ENST00000424558A0A0C4DG21
ENSG00000138443ENST00000425253F8WCD7
ENSG00000138443ENST00000430418E9PEZ7
ENSG00000138443ENST00000431886F8WEB9
ENSG00000138443ENST00000441061F8WAQ3
ENSG00000138443ENST00000444584E7EUA1
ENSG00000138443ENST00000447762F8WAZ8
ENSG00000138443ENST00000451591H7C3Q7
ENSG00000138443ENST00000454023H0Y6B5

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191582782009Regulation of cell-cell adhesion by Abi/Diaphanous complexes.49
186326092008Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.42
173896882007Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway.16
171011332006NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.13
223048322012Abl-interactor 2 (ABI2): a novel MLL translocation partner in acute myeloid leukemia.4
164889062006The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta.1
279323142017TIS21/BTG2 inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade.1

Citation

Dessen P

ABI2 (abl interactor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/494/abi2