ADK (adenosine kinase)

2003-11-01  

Identity

HGNC
LOCATION
10q22.2
LOCUSID
ALIAS
AK
FUSION GENES

Other Information

Locus ID:

NCBI: 132
MIM: 102750
HGNC: 257
Ensembl: ENSG00000156110

Variants:

dbSNP: 132
ClinVar: 132
TCGA: ENSG00000156110
COSMIC: ADK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156110ENST00000286621P55263
ENSG00000156110ENST00000372734P55263
ENSG00000156110ENST00000372734A0A140VJE0
ENSG00000156110ENST00000539909P55263
ENSG00000156110ENST00000541550P55263

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Purine metabolismREACTOMER-HSA-73847
Purine salvageREACTOMER-HSA-74217

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448004abacavirChemicalPathwayassociated24625462

References

Pubmed IDYearTitleCitations
183090312008HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
216352412011Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.39
196354622009Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus.26
203925012010Contribution of adenosine related genes to the risk of depression with disturbed sleep.20
220921112012Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy.18
208811342010Manipulation of adenosine kinase affects sleep regulation in mice.17
206988272010Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy.16
260409192015Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.14

Citation

Dessen P

ADK (adenosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/583/adk