API5 (apoptosis inhibitor 5)

2003-08-01  

Identity

HGNC
LOCATION
11p12
LOCUSID
ALIAS
AAC-11,AAC11
FUSION GENES

Other Information

Locus ID:

NCBI: 8539
MIM: 609774
HGNC: 594
Ensembl: ENSG00000166181

Variants:

dbSNP: 8539
ClinVar: 8539
TCGA: ENSG00000166181
COSMIC: API5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166181ENST00000378852Q9BZZ5
ENSG00000166181ENST00000420461Q9BZZ5
ENSG00000166181ENST00000455725Q9BZZ5
ENSG00000166181ENST00000526394H0YER7
ENSG00000166181ENST00000531273Q9BZZ5
ENSG00000166181ENST00000534600G3V1C3
ENSG00000166181ENST00000534695E9PQK6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183192552008Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target.135
171123192006Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo.49
193874942009The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation.33
198211572010Pim-2 activates API-5 to inhibit the apoptosis of hepatocellular carcinoma cells through NF-kappaB pathway.18
254773742015Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon.16
247694422014API5 confers tumoral immune escape through FGF2-dependent cell survival pathway.14
239407552013Api5 contributes to E2F1 control of the G1/S cell cycle phase transition.13
250700702014Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancer.13
266736632015Nucleoprotein of influenza A virus negatively impacts antiapoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication.13
206716112010Gene expression levels of CSNK1A1 and AAC-11, but not NME1, in tumor tissues as prognostic factors in NSCLC patients.11

Citation

Dessen P

API5 (apoptosis inhibitor 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/675/api5