ARID2 (AT-rich interaction domain 2)

2011-10-01 Affiliation

Identity

HGNC

ARID2

LOCATION

12q12

LOCUSID

196528

ALIAS

BAF200,CSS6,p200

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 196528
MIM: 609539
HGNC: 18037
Ensembl: ENSG00000189079

Variants:

dbSNP: 196528
ClinVar: 196528
TCGA: ENSG00000189079
COSMIC: ARID2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000189079	ENST00000334344	Q68CP9
ENSG00000189079	ENST00000422737	F8WCU9
ENSG00000189079	ENST00000444670	F8W108
ENSG00000189079	ENST00000457135	F8VWP4
ENSG00000189079	ENST00000477947	A0A087WY37

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
RMTs methylate histone arginines	REACTOME	R-HSA-3214858

References

Pubmed ID	Year	Title	Citations
21822264	2011	Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.	165
24382590	2014	Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer.	40
25636086	2015	Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.	40
26716708	2015	Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes.	30
23047306	2013	Recurrent inactivating mutations of ARID2 in non-small cell lung carcinoma.	25
22095441	2011	ARID2: a new tumor suppressor gene in hepatocellular carcinoma.	23
27035278	2016	MicroRNA-155 promotes tumor growth of human hepatocellular carcinoma by targeting ARID2.	16
26238514	2015	Mutations in ARID2 are associated with intellectual disabilities.	13
27351279	2016	Chromatin remodeling gene ARID2 targets cyclin D1 and cyclin E1 to suppress hepatoma cell progression.	13
16782067	2006	Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation.	12

Citation

Dessen P

ARID2 (AT-rich interaction domain 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52470/arid2