ARL6IP1 (ADP ribosylation factor like GTPase 6 interacting protein 1)

2010-08-01  

Identity

HGNC
ARL6IP1
LOCATION
16p12.3
LOCUSID
23204
ALIAS
AIP1,ARL6IP,ARMER,SPG61
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23204
MIM: 607669
HGNC: 697
Ensembl: ENSG00000170540

Variants:

dbSNP: 23204
ClinVar: 23204
TCGA: ENSG00000170540
COSMIC: ARL6IP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170540ENST00000304414Q15041
ENSG00000170540ENST00000304414A0A024QYV7
ENSG00000170540ENST00000546206Q15041
ENSG00000170540ENST00000562234H3BPJ2
ENSG00000170540ENST00000562819H3BTX6
ENSG00000170540ENST00000563861H3BS91

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
127542982003ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis.6
203728632010ARL6IP1 mediates cisplatin-induced apoptosis in CaSki cervical cancer cells.6
240760292013Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline.4
202135092010Inhibition of ADP-ribosylation factor-like 6 interacting protein 1 suppresses proliferation and reduces tumor cell invasion in CaSki human cervical cancer cells.3
312724222019Truncating ARL6IP1 variant as the genetic cause of fatal complicated hereditary spastic paraplegia.1

Citation

Dessen P

ARL6IP1 (ADP ribosylation factor like GTPase 6 interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51569/arl6ip1