ARPC4 (actin related protein 2/3 complex subunit 4)

2013-06-01  

Identity

HGNC
LOCATION
3p25.3
LOCUSID
ALIAS
ARC20,P20-ARC
FUSION GENES

Other Information

Locus ID:

NCBI: 10093
MIM: 604226
HGNC: 707
Ensembl: ENSG00000241553

Variants:

dbSNP: 10093
ClinVar: 10093
TCGA: ENSG00000241553
COSMIC: ARPC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241553ENST00000397261P59998
ENSG00000241553ENST00000417500F8WDW3
ENSG00000241553ENST00000433034P59998
ENSG00000241553ENST00000440787F8WDD7
ENSG00000241553ENST00000485273R4GN08
ENSG00000241553ENST00000498623P59998

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Pathogenic Escherichia coli infectionKEGGko05130
Regulation of actin cytoskeletonKEGGhsa04810
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

References

Pubmed IDYearTitleCitations
172749802007Coronin 3 involvement in F-actin-dependent processes at the cell cortex.19
232671272013Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration.17
238945632013Expression of the ARPC4 subunit of human Arp2/3 severely affects mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages.3

Citation

Dessen P

ARPC4 (actin related protein 2/3 complex subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53405/arpc4