BDNF (brain derived neurotrophic factor)

2007-02-01  

Identity

HGNC
LOCATION
11p14.1
LOCUSID
ALIAS
ANON2,BULN2
FUSION GENES

Other Information

Locus ID:

NCBI: 627
MIM: 113505
HGNC: 1033
Ensembl: ENSG00000176697

Variants:

dbSNP: 627
ClinVar: 627
TCGA: ENSG00000176697
COSMIC: BDNF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176697ENST00000314915P23560
ENSG00000176697ENST00000356660P23560
ENSG00000176697ENST00000356660A0A0E3SU01
ENSG00000176697ENST00000395978P23560
ENSG00000176697ENST00000395978A0A0E3SU01
ENSG00000176697ENST00000395980P23560
ENSG00000176697ENST00000395980A0A0E3SU01
ENSG00000176697ENST00000395981P23560
ENSG00000176697ENST00000395981A0A0E3SU01
ENSG00000176697ENST00000395983P23560
ENSG00000176697ENST00000395983A0A0E3SU01
ENSG00000176697ENST00000395986P23560
ENSG00000176697ENST00000418212P23560
ENSG00000176697ENST00000418212A0A0E3SU01
ENSG00000176697ENST00000420794P23560
ENSG00000176697ENST00000420794A0A0E3SU01
ENSG00000176697ENST00000438929P23560
ENSG00000176697ENST00000439476P23560
ENSG00000176697ENST00000439476A0A0E3SU01
ENSG00000176697ENST00000525528P23560
ENSG00000176697ENST00000525528A0A0E3SU01
ENSG00000176697ENST00000525950P23560
ENSG00000176697ENST00000525950A0A0E3SU01
ENSG00000176697ENST00000530786E9PMP3
ENSG00000176697ENST00000530861P23560
ENSG00000176697ENST00000530861A0A0E3SU01
ENSG00000176697ENST00000532997P23560
ENSG00000176697ENST00000532997A0A0E3SU01
ENSG00000176697ENST00000533131P23560
ENSG00000176697ENST00000533131A0A0E3SU01
ENSG00000176697ENST00000533246P23560
ENSG00000176697ENST00000533246A0A0E3SU01

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Huntington's diseaseKEGGko05016
MAPK signaling pathwayKEGGhsa04010
Huntington's diseaseKEGGhsa05016
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10074escitalopramChemicalClinicalAnnotationassociatedPD19641488
PA128406954Weight gainDiseaseMultilinkAnnotationassociated24279860
PA164712362AnalgesicsChemicalClinicalAnnotationassociated25096645
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociated25096645
PA164712741Ergot alkaloidsChemicalClinicalAnnotationassociated25096645
PA164713257Selective serotonin reuptake inhibitorsChemicalLiterature, MultilinkAnnotationassociated24930681
PA166119022methamphetamine dependenceDiseaseClinicalAnnotationassociatedPD
PA444460Heroin DependenceDiseaseClinicalAnnotation, MultilinkAnnotationassociatedPD23651024, 24279859
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD23651024
PA446876Substance-Related DisordersDiseaseClinicalAnnotationassociatedPD24279859, 26401760, 28692418
PA447207Depressive DisorderDiseaseClinicalAnnotationassociatedPD19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD16633140, 24595507, 25560300
PA447278DepressionDiseaseClinicalAnnotationassociatedPD
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD19236730, 19641488, 20016225, 21338649, 22965830, 23619509, 29748862
PA449015citalopramChemicalClinicalAnnotationassociatedPD19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862
PA449233desipramineChemicalClinicalAnnotationassociatedPD
PA449673fluoxetineChemicalClinicalAnnotationassociatedPD20016225
PA450243lithiumChemicalLiterature, MultilinkAnnotationassociated24885933
PA450401methadoneChemicalClinicalAnnotationassociatedPD23651024
PA450403methamphetamineChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD24279859, 26401760, 28692418
PA450657nortriptylineChemicalClinicalAnnotationassociatedPD19641488
PA450688olanzapineChemicalClinicalAnnotationassociatedPD24595507
PA450801paroxetineChemicalClinicalAnnotationassociatedPD19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862
PA451566sumatriptanChemicalClinicalAnnotationassociated25096645
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD16633140, 25560300
PA452618opioidsChemicalClinicalAnnotationassociated25096645
PA452619heroinChemicalClinicalAnnotationassociatedPD24279859, 26401760, 28692418

References

Pubmed IDYearTitleCitations
125539132003The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.983
190792602009Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.517
204188902010Genome-wide meta-analyses identify multiple loci associated with smoking behavior.463
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
128907612003Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance.318
128907612003Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance.318
155378792004The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.294
195069062009Candidate gene studies of ADHD: a meta-analytic review.263
200752152010A genetic variant BDNF polymorphism alters extinction learning in both mouse and human.237
200752152010A genetic variant BDNF polymorphism alters extinction learning in both mouse and human.237

Citation

Dessen P

BDNF (brain derived neurotrophic factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46287/bdnf