CDK11B (cyclin dependent kinase 11B)

2003-06-01  

Identity

HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
CDC2L1,CDK11,CDK11-p110,CDK11-p46,CDK11-p58,CLK-1,PITSLREA,PK58,p58,p58CDC2L1,p58CLK-1
FUSION GENES

Other Information

Locus ID:

NCBI: 984
MIM: 176873
HGNC: 1729
Ensembl: ENSG00000248333

Variants:

dbSNP: 984
ClinVar: 984
TCGA: ENSG00000248333
COSMIC: CDK11B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000248333ENST00000340677P21127
ENSG00000248333ENST00000341832P21127
ENSG00000248333ENST00000407249P21127
ENSG00000248333ENST00000611150A0A087X1I0
ENSG00000248333ENST00000615951A0A087WYI9
ENSG00000248333ENST00000626918A0A0D9SEI3
ENSG00000248333ENST00000629289A0A0D9SER5
ENSG00000248333ENST00000629312A0A0D9SEN2

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
153307582005Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.40
176985822007Cyclin D3/CDK11p58 complex is involved in the repression of androgen receptor.30
227918842012Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation.27
198541362009HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8.26
240078622014Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells.21
258373262015Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.19
120820952002Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3.18
253486122015Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system.18
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.16
265675092015CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing.16

Citation

Dessen P

CDK11B (cyclin dependent kinase 11B)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40008/cdk11b