CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1)

2003-05-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
CDK5P35,CDK5R,NCK5A,p23,p25,p35,p35nck5a

Other Information

Locus ID:

NCBI: 8851
MIM: 603460
HGNC: 1775
Ensembl: ENSG00000176749

Variants:

dbSNP: 8851
ClinVar: 8851
TCGA: ENSG00000176749
COSMIC: CDK5R1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176749ENST00000313401Q15078
ENSG00000176749ENST00000584716J3QRB5
ENSG00000176749ENST00000584792J3QRB5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Alzheimer's diseaseKEGGko05010
Alzheimer's diseaseKEGGhsa05010
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
DiseaseREACTOMER-HSA-1643685
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
CRMPs in Sema3A signalingREACTOMER-HSA-399956
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803

References

Pubmed IDYearTitleCitations
90102031997Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality.185
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
170360522006A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death.61
122260932002Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.39
216253872011The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration.39
122305542002A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells.35
157412322005p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death.34
188299672008Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5.33
217720612011Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition.32

Citation

Dessen P

CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40034/cdk5r1