CLEC14A (C-type lectin domain containing 14A)

2012-04-01  

Identity

HGNC
CLEC14A
LOCATION
14q21.1
LOCUSID
161198
ALIAS
C14orf27,CEG1,EGFR-5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 161198
MIM: 616845
HGNC: 19832
Ensembl: ENSG00000176435

Variants:

dbSNP: 161198
ClinVar: 161198
TCGA: ENSG00000176435
COSMIC: CLEC14A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176435ENST00000342213Q86T13

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
217060542012Identification and angiogenic role of the novel tumor endothelial marker CLEC14A.41
239797072013SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.25
257459972015Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth.19
257459972015Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth.19
286716702017Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.15
236446592013Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro.12
301321502019Activin receptor-like kinase 1 is associated with immune cell infiltration and regulates CLEC14A transcription in cancer.6
301919702019Methylation of CLEC14A is associated with its expression and lung adenocarcinoma progression.2
318528882019Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.1

Citation

Dessen P

CLEC14A (C-type lectin domain containing 14A)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52670/clec14a