CRHBP (corticotropin releasing hormone binding protein)

2012-01-01  

Identity

HGNC
LOCATION
5q13.3
LOCUSID
ALIAS
CRF-BP,CRFBP

Other Information

Locus ID:

NCBI: 1393
MIM: 122559
HGNC: 2356
Ensembl: ENSG00000145708

Variants:

dbSNP: 1393
ClinVar: 1393
TCGA: ENSG00000145708
COSMIC: CRHBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145708ENST00000274368P24387
ENSG00000145708ENST00000506501D6RHH7

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD21039637
PA448073ethanolChemicalClinicalAnnotationassociatedPD21039637

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.92
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
163685642006CRH-BP: the regulation and function of a phylogenetically conserved binding protein.42
189748512008Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP.42
189748512008Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP.42
219785462012Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.42
210396372011Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.40
210396372011Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.40
195788762009The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.39

Citation

Dessen P

CRHBP (corticotropin releasing hormone binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52564/crhbp