CTSD (cathepsin D)

2003-06-01 Affiliation

Identity

HGNC

CTSD

LOCATION

11p15.5

LOCUSID

1509

ALIAS

CLN10,CPSD,HEL-S-130P

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1509
MIM: 116840
HGNC: 2529
Ensembl: ENSG00000117984

Variants:

dbSNP: 1509
ClinVar: 1509
TCGA: ENSG00000117984
COSMIC: CTSD

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000117984	ENST00000236671	P07339
ENSG00000117984	ENST00000236671	V9HWI3
ENSG00000117984	ENST00000367196	F8W787
ENSG00000117984	ENST00000429746	H7C1V0
ENSG00000117984	ENST00000433655	F8WD96
ENSG00000117984	ENST00000438213	C9JH19
ENSG00000117984	ENST00000636571	A0A1B0GW44
ENSG00000117984	ENST00000636843	A0A1B0GWE8
ENSG00000117984	ENST00000637381	A0A1B0GV01
ENSG00000117984	ENST00000637387	A0A1B0GVP3
ENSG00000117984	ENST00000637815	A0A1B0GV23
ENSG00000117984	ENST00000637915	A0A1B0GVD5

Expression (GTEx)

500

1000

1500

2000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Autophagy - animal	KEGG	ko04140
Apoptosis	KEGG	ko04210
Autophagy - animal	KEGG	hsa04140
Apoptosis	KEGG	hsa04210
Lysosome	KEGG	ko04142
Lysosome	KEGG	hsa04142
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Metabolism of Angiotensinogen to Angiotensins	REACTOME	R-HSA-2022377
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
MHC class II antigen presentation	REACTOME	R-HSA-2132295
Innate Immune System	REACTOME	R-HSA-168249
Extracellular matrix organization	REACTOME	R-HSA-1474244
Degradation of the extracellular matrix	REACTOME	R-HSA-1474228
Collagen degradation	REACTOME	R-HSA-1442490
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17289576	2007	A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.	183
12782632	2003	Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis.	105
18702517	2008	Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species.	94
16046058	2006	Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis.	87
19203374	2009	Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.	86
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
18367545	2008	Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.	62
12185597	2002	Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis.	50
21948970	2011	AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.	46
19950226	2010	Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women.	45

Citation

Dessen P

CTSD (cathepsin D)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40203/ctsd