CTSE (cathepsin E)

2003-06-01  

Identity

HGNC
CTSE
LOCATION
1q32.1
LOCUSID
1510
ALIAS
CATE

Other Information

Locus ID:

NCBI: 1510
MIM: 116890
HGNC: 2530
Ensembl: ENSG00000196188

Variants:

dbSNP: 1510
ClinVar: 1510
TCGA: ENSG00000196188
COSMIC: CTSE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196188ENST00000358184P14091
ENSG00000196188ENST00000360218P14091

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
180068322007Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface.28
156991052005The expression and function of cathepsin E in dendritic cells.21
220681662012Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models.21
147698792003Association of cathepsin E deficiency with development of atopic dermatitis.15
191722912009Over-expression of cathepsin E and trefoil factor 1 in sessile serrated adenomas of the colorectum identified by gene expression analysis.15
158453572005Modeling the tertiary structure of human cathepsin-E.14
252395632014Cathepsin E promotes pulmonary emphysema via mitochondrial fission.12
206006292010Selective detection of Cathepsin E proteolytic activity.11
216649912012Emerging roles of cathepsin E in host defense mechanisms.11
242423302014Repression of cathepsin E expression increases the risk of mammary carcinogenesis and links to poor prognosis in breast cancer.11

Citation

Dessen P

CTSE (cathepsin E)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40204/ctse