CTSF (cathepsin F)

2007-02-01  

Identity

HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
CATSF,CLN13
FUSION GENES

Other Information

Locus ID:

NCBI: 8722
MIM: 603539
HGNC: 2531
Ensembl: ENSG00000174080

Variants:

dbSNP: 8722
ClinVar: 8722
TCGA: ENSG00000174080
COSMIC: CTSF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174080ENST00000310325Q9UBX1
ENSG00000174080ENST00000524994H0YD65
ENSG00000174080ENST00000525733H0YE42
ENSG00000174080ENST00000526010E9PSC2

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
ApoptosisKEGGhsa04210
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
159896932005Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer.30
151843812004Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro.25
232973592013Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis.25
242550362013Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing.18
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
169630532007Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect.9
255768722015Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease.5
275245082016Exome sequencing in a consanguineous family clinically diagnosed with early-onset Alzheimer's disease identifies a homozygous CTSF mutation.4
284745742018Cathepsin F Knockdown Induces Proliferation and Inhibits Apoptosis in Gastric Cancer Cells.3

Citation

Dessen P

CTSF (cathepsin F)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45683/ctsf