CUL2 (cullin 2)

2003-02-01  

Identity

HGNC
LOCATION
10p11.21
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 8453
MIM: 603135
HGNC: 2552
Ensembl: ENSG00000108094

Variants:

dbSNP: 8453
ClinVar: 8453
TCGA: ENSG00000108094
COSMIC: CUL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108094ENST00000374746Q5T2B5
ENSG00000108094ENST00000374748Q13617
ENSG00000108094ENST00000374748A0A140VKB1
ENSG00000108094ENST00000374749Q13617
ENSG00000108094ENST00000374749A0A140VKB1
ENSG00000108094ENST00000374751Q13617
ENSG00000108094ENST00000374751A0A140VKB1
ENSG00000108094ENST00000374754Q5T2B7
ENSG00000108094ENST00000421317Q13617
ENSG00000108094ENST00000537177A0A0A0MTN0
ENSG00000108094ENST00000626172Q5T2B5
ENSG00000108094ENST00000673636A0A140VKB1

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Renal cell carcinomaKEGGko05211
Ubiquitin mediated proteolysisKEGGhsa04120
Pathways in cancerKEGGhsa05200
Renal cell carcinomaKEGGhsa05211
ECV complexKEGGhsa_M00383
HIF-1 signaling pathwayKEGGhsa04066
ECV complexKEGGM00383
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to hypoxiaREACTOMER-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygenREACTOMER-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaREACTOMER-HSA-1234176

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176092712007Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor.109
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
298441242018Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma.42
225373862012UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.28
253265372015Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses.23
218222152011The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.18
229127442012The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.15
285916242017Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.15
183722492008CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis.12
293672462018Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation.12

Citation

Dessen P

CUL2 (cullin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40212/cul2