CXCL1 (C-X-C motif chemokine ligand 1)

2003-02-01  

Identity

HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
FSP,GRO1,GROa,MGSA,MGSA-a,NAP-3,SCYB1
FUSION GENES

Other Information

Locus ID:

NCBI: 2919
MIM: 155730
HGNC: 4602
Ensembl: ENSG00000163739

Variants:

dbSNP: 2919
ClinVar: 2919
TCGA: ENSG00000163739
COSMIC: CXCL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163739ENST00000395761P09341

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Cytokine-cytokine receptor interactionKEGGhsa04060
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Neutrophil degranulationREACTOMER-HSA-6798695
Interleukin-10 signalingREACTOMER-HSA-6783783
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

References

Pubmed IDYearTitleCitations
227702182012A CXCL1 paracrine network links cancer chemoresistance and metastasis.320
129492492003Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.154
170606212006The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis.121
165673912006CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer.120
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
270499442016The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression.95
219941222012CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling.80
179999912008Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB.55
145303672003IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation.49
160863662006Role for CXCR2 and CXCL1 on glia in multiple sclerosis.43

Citation

Dessen P

CXCL1 (C-X-C motif chemokine ligand 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40217/cxcl1