CXXC4 (CXXC finger protein 4)

2003-05-01  

Identity

HGNC
LOCATION
4q24
LOCUSID
ALIAS
IDAX
FUSION GENES

Other Information

Locus ID:

NCBI: 80319
MIM: 611645
HGNC: 24593
Ensembl: ENSG00000168772

Variants:

dbSNP: 80319
ClinVar: 80319
TCGA: ENSG00000168772
COSMIC: CXXC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168772ENST00000394767J9JIF5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Negative regulation of TCF-dependent signaling by DVL-interacting proteinsREACTOMER-HSA-5368598

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713176Platinum compoundsChemicalClinicalAnnotationassociatedPD24980784
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD24980784

References

Pubmed IDYearTitleCitations
235632672013Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.121
189316982009Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling.26
239492252013Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4.17
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
293370632018BMI1 activates WNT signaling in colon cancer by negatively regulating the WNT antagonist IDAX.6
250648422014New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling.4
250850162014CXXC4 mRNA levels are associated with clinicopathological parameters and survival of myelodysplastic syndrome patients.3
300421692018MiR-629-5p promotes colorectal cancer progression through targetting CXXC finger protein 4.1

Citation

Dessen P

CXXC4 (CXXC finger protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40226/cxxc4