DEFB103B (defensin beta 103B)

2010-08-01  

Identity

HGNC
LOCATION
8p23.1
LOCUSID
ALIAS
BD-3,DEFB-3,DEFB103,DEFB3,HBD-3,HBD3,HBP-3,HBP3

Other Information

Locus ID:

NCBI: 55894
MIM: 606611
HGNC: 31702
Ensembl: ENSG00000177243

Variants:

dbSNP: 55894
ClinVar: 55894
TCGA: ENSG00000177243
COSMIC: DEFB103B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177243ENST00000318124P81534

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DefensinsREACTOMER-HSA-1461973
Beta defensinsREACTOMER-HSA-1461957
Antimicrobial peptidesREACTOMER-HSA-6803157

References

Pubmed IDYearTitleCitations
128401472003Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3.117
180066612007Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.103
204837502010Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.92
117419802002The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus.83
168187312006Cutting edge: human beta defensin 3--a novel antagonist of the HIV-1 coreceptor CXCR4.81
203857532010Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci.78
112232602001Discovery of new human beta-defensins using a genomics-based approach.57
160341192005The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes.56
201044912010Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo.55
255125262014pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37.53

Citation

Dessen P

DEFB103B (defensin beta 103B)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51609/defb103b