DRD3 (dopamine receptor D3)

2011-02-01 Affiliation

Identity

HGNC

DRD3

LOCATION

3q13.31

LOCUSID

1814

ALIAS

D3DR,ETM1,FET1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1814
MIM: 126451
HGNC: 3024
Ensembl: ENSG00000151577

Variants:

dbSNP: 1814
ClinVar: 1814
TCGA: ENSG00000151577
COSMIC: DRD3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000151577	ENST00000295881	E9PCM4
ENSG00000151577	ENST00000383673	P35462
ENSG00000151577	ENST00000383673	X5D2G4
ENSG00000151577	ENST00000460779	P35462
ENSG00000151577	ENST00000460779	X5D2G4
ENSG00000151577	ENST00000467632	P35462
ENSG00000151577	ENST00000467632	X5D2G4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Dopamine receptors	REACTOME	R-HSA-390651
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10066	duloxetine	Chemical	ClinicalAnnotation	associated		PD	22249355
PA153906318	Autism Spectrum Disorder	Disease	ClinicalAnnotation	associated		PD	23856854
PA164742949	pramipexole	Chemical	ClinicalAnnotation	associated		PD	19396436
PA444339	Hallucinations	Disease	ClinicalAnnotation	associated		PD	30794329
PA445208	Pain	Disease	VariantAnnotation	not associated		PD	21398039
PA445254	Parkinson Disease	Disease	ClinicalAnnotation	associated		PD	19396436, 27779245, 30794329
PA447196	Anxiety Disorders	Disease	ClinicalAnnotation	associated		PD	22249355
PA447198	Autistic Disorder	Disease	ClinicalAnnotation	associated		PD	19997080
PA447199	Bipolar Disorder	Disease	ClinicalAnnotation	associated		PD	19506579
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated		PD	18320559, 19506579, 20029384, 21332319
PA447230	HIV	Disease	ClinicalAnnotation	associated		PD	21491142
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated		PD	22926616
PA449061	clozapine	Chemical	ClinicalAnnotation	associated		PD	20029384, 21332319
PA450213	levodopa	Chemical	ClinicalAnnotation	associated		PD	27779245, 30794329
PA450403	methamphetamine	Chemical	ClinicalAnnotation	associated		PD	21491142
PA450464	methylphenidate	Chemical	ClinicalAnnotation	associated		PD	23856854
PA450688	olanzapine	Chemical	ClinicalAnnotation	associated		PD	18320559
PA450801	paroxetine	Chemical	ClinicalAnnotation	associated		PD	22926616
PA451201	quetiapine	Chemical	ClinicalAnnotation	associated	PK		25025989
PA451257	risperidone	Chemical	ClinicalAnnotation	associated		PD	19506579, 19997080
PA452618	opioids	Chemical	VariantAnnotation	not associated		PD	21398039

References

Pubmed ID	Year	Title	Citations
18583979	2008	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	395
21097933	2010	Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.	368
19506906	2009	Candidate gene studies of ADHD: a meta-analytic review.	263
19874574	2009	Genetical genomic determinants of alcohol consumption in rats and humans.	93
20351714	2011	Poor replication of candidate genes for major depressive disorder using genome-wide association data.	92
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
18644790	2008	Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum.	66
18424554	2008	Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization.	62
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
12808427	2003	Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis.	59

Citation

Dessen P

DRD3 (dopamine receptor D3)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52045/drd3