EIF4A3 (eukaryotic translation initiation factor 4A3)

2007-02-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
DDX48,Fal1,MUK34,NMP265,NUK34,RCPS,eIF-4A-III,eIF4A-III,eIF4AIII
FUSION GENES

Other Information

Locus ID:

NCBI: 9775
MIM: 608546
HGNC: 18683
Ensembl: ENSG00000141543

Variants:

dbSNP: 9775
ClinVar: 9775
TCGA: ENSG00000141543
COSMIC: EIF4A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141543ENST00000576547I3L3H2
ENSG00000141543ENST00000647795P38919
ENSG00000141543ENST00000647795A0A024R8W0
ENSG00000141543ENST00000649764P38919
ENSG00000141543ENST00000649764A0A024R8W0

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Exon junction complex (EJC)KEGGhsa_M00430
Exon junction complex (EJC)KEGGM00430
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169317182006Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.159
176320642007The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression.135
149734902004An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay.132
161703252005The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.115
150345512004eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay.102
269890252016Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3.75
304702622018EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis.38
229613802012Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly.35
243608102014A noncoding expansion in EIF4A3 causes Richieri-Costa-Pereira syndrome, a craniofacial disorder associated with limb defects.29
184275452008The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers.26

Citation

Dessen P

EIF4A3 (eukaryotic translation initiation factor 4A3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46533/eif4a3