ERO1A (endoplasmic reticulum oxidoreductase 1 alpha)

2007-02-01  

Identity

HGNC
LOCATION
14q22.1
LOCUSID
ALIAS
ERO1-L,ERO1-L-alpha,ERO1-alpha,ERO1L,ERO1LA,Ero1alpha
FUSION GENES

Other Information

Locus ID:

NCBI: 30001
MIM: 615435
HGNC: 13280
Ensembl: ENSG00000197930

Variants:

dbSNP: 30001
ClinVar: 30001
TCGA: ENSG00000197930
COSMIC: ERO1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197930ENST00000395686Q96HE7
ENSG00000197930ENST00000554019G3V3E6
ENSG00000197930ENST00000554251G3V5B3
ENSG00000197930ENST00000556039G3V3E6
ENSG00000197930ENST00000556223G3V503
ENSG00000197930ENST00000556358G3V2H0
ENSG00000197930ENST00000629528G3V3E6

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Vibrio cholerae infectionKEGGko05110
Vibrio cholerae infectionKEGGhsa05110
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188331922008A novel disulphide switch mechanism in Ero1alpha balances ER oxidation in human cells.71
189719432008Low reduction potential of Ero1alpha regulatory disulphides ensures tight control of substrate oxidation.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
218542142012Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM).57
201865082010Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM).54
208024622010Disulphide production by Ero1α-PDI relay is rapid and effectively regulated.50
208342322010Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI.49
155925002005Ero1-L alpha plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer.48
151619132004Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum.46
200958662010Redox state of the endoplasmic reticulum is controlled by Ero1L-alpha and intraluminal calcium.44

Citation

Dessen P

ERO1A (endoplasmic reticulum oxidoreductase 1 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45895/ero1a