F2RL2 (coagulation factor II thrombin receptor like 2)

2010-10-01  

Identity

HGNC
LOCATION
5q13.3
LOCUSID
ALIAS
PAR-3,PAR3

Other Information

Locus ID:

NCBI: 2151
MIM: 601919
HGNC: 3539
Ensembl: ENSG00000164220

Variants:

dbSNP: 2151
ClinVar: 2151
TCGA: ENSG00000164220
COSMIC: F2RL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164220ENST00000296641O00254
ENSG00000164220ENST00000504899O00254

Expression (GTEx)

0
1
2
3
4
5
6
7

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Complement and coagulation cascadesKEGGko04610
Neuroactive ligand-receptor interactionKEGGhsa04080
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
173768662007Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization.73
128050692003Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells.48
204546802010Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear.25
195869012009Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A.17
194739692009Stabilization of the E* form turns thrombin into an anticoagulant.16
182648012008The protease-activated receptor-3 (PAR-3) can signal autonomously to induce interleukin-8 release.14
253202422014Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity.12
145151922003Evidence for functionally active protease-activated receptor-3 (PAR-3) in human vascular smooth muscle cells.11
204422982010Thrombin regulates the metastatic potential of human rhabdomyosarcoma cells: distinct role of PAR1 and PAR3 signaling.11

Citation

Dessen P

F2RL2 (coagulation factor II thrombin receptor like 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51702/f2rl2