FAM3B (FAM3 metabolism regulating signaling molecule B)

2013-02-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
2-21,C21orf11,C21orf76,ORF9,PANDER,PRED44
FUSION GENES

Other Information

Locus ID:

NCBI: 54097
MIM: 608617
HGNC: 1253
Ensembl: ENSG00000183844

Variants:

dbSNP: 54097
ClinVar: 54097
TCGA: ENSG00000183844
COSMIC: FAM3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183844ENST00000357985P58499
ENSG00000183844ENST00000398646A8MTF8
ENSG00000183844ENST00000398647P58499
ENSG00000183844ENST00000398652P58499

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
121607272002Cloning, expression, and initial characterization of a novel cytokine-like gene family.48
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
162494482005Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells.19
230597592013A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.13
161148712005Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells.9
244686802014PANDER transgenic mice display fasting hyperglycemia and hepatic insulin resistance.7
271811092016Elevated circulating level of a cytokine, pancreatic-derived factor, is associated with metabolic syndrome components in a Chinese population.7
232464872013Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway.6
238553042013Family with sequence similarity 3 gene family and nonalcoholic fatty liver disease.5

Citation

Dessen P

FAM3B (FAM3 metabolism regulating signaling molecule B)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53174/fam3b