FAR2 (fatty acyl-CoA reductase 2)

2014-11-01  

Identity

HGNC
FAR2
LOCATION
12p11.22
LOCUSID
55711
ALIAS
HEL-S-81,MLSTD1,SDR10E2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55711
MIM: 616156
HGNC: 25531
Ensembl: ENSG00000064763

Variants:

dbSNP: 55711
ClinVar: 55711
TCGA: ENSG00000064763
COSMIC: FAR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064763ENST00000182377Q96K12
ENSG00000064763ENST00000182377A0A024RAW7
ENSG00000064763ENST00000536681Q96K12
ENSG00000064763ENST00000536681A0A024RAW7
ENSG00000064763ENST00000547116Q96K12
ENSG00000064763ENST00000547759H0YHP1
ENSG00000064763ENST00000551193H0YIE0
ENSG00000064763ENST00000551451F8VPF2
ENSG00000064763ENST00000552137F8VX60

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Wax biosynthesisREACTOMER-HSA-8848584

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
152203482004Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
152203492004Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family.37
296526352018FAR2 is associated with kidney disease in mice and humans.4

Citation

Dessen P

FAR2 (fatty acyl-CoA reductase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63295/far2