FBXW11 (F-box and WD repeat domain containing 11)

2015-10-01  

Identity

HGNC
LOCATION
5q35.1
LOCUSID
ALIAS
BTRC2,BTRCP2,FBW1B,FBXW1B,Fbw11,Hos,NEDJED
FUSION GENES

Other Information

Locus ID:

NCBI: 23291
MIM: 605651
HGNC: 13607
Ensembl: ENSG00000072803

Variants:

dbSNP: 23291
ClinVar: 23291
TCGA: ENSG00000072803
COSMIC: FBXW11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072803ENST00000265094Q9UKB1
ENSG00000072803ENST00000296933Q9UKB1
ENSG00000072803ENST00000393802Q9UKB1
ENSG00000072803ENST00000517395E5RGC1
ENSG00000072803ENST00000518752E5RH92
ENSG00000072803ENST00000519693E5RG78
ENSG00000072803ENST00000520376E5RG78
ENSG00000072803ENST00000523843E5RG78

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Wnt signaling pathwayKEGGko04310
Hedgehog signaling pathwayKEGGko04340
Circadian rhythmKEGGko04710
Ubiquitin mediated proteolysisKEGGhsa04120
Wnt signaling pathwayKEGGhsa04310
Hedgehog signaling pathwayKEGGhsa04340
Circadian rhythmKEGGhsa04710
ShigellosisKEGGhsa05131
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
SCF-BTRC complexKEGGhsa_M00380
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
SCF-BTRC complexKEGGM00380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Downstream TCR signalingREACTOMER-HSA-202424
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
Activation of NF-kappaB in B cellsREACTOMER-HSA-1169091
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated NF-kB activationREACTOMER-HSA-2871837
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764
Dectin-1 mediated noncanonical NF-kB signalingREACTOMER-HSA-5607761
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
NIK-->noncanonical NF-kB signalingREACTOMER-HSA-5676590
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
MAP3K8 (TPL2)-dependent MAPK1/3 activationREACTOMER-HSA-5684264

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
236117802013MicroRNA-106b-25 cluster targets β-TRCP2, increases the expression of Snail and enhances cell migration and invasion in H1299 (non small cell lung cancer) cells.30
253322352015Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.26
220458532011Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1.16
228516932012β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation.15
211387642011Specificity, location and function of βTrCP isoforms and their splice variants.6
168652942006Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1.5
295559462018Fbxw11 promotes the proliferation of lymphocytic leukemia cells through the concomitant activation of NF-κB and β-catenin/TCF signaling pathways.5
316859922019PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.4
300311112018β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.0
314020902019De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies.0

Citation

Dessen P

FBXW11 (F-box and WD repeat domain containing 11)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55423/fbxw11