FNTB (farnesyltransferase, CAAX box, beta)

2013-01-01  

Identity

HGNC
FNTB
LOCATION
14q23.3
LOCUSID
2342
ALIAS
FPTB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2342
MIM: 134636
HGNC: 3785
Ensembl: ENSG00000257365

Variants:

dbSNP: 2342
ClinVar: 2342
TCGA: ENSG00000257365
COSMIC: FNTB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000257365ENST00000246166P49356
ENSG00000257365ENST00000246166A0A384MEJ5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Terpenoid backbone biosynthesisKEGGko00900
Terpenoid backbone biosynthesisKEGGhsa00900
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The phototransduction cascadeREACTOMER-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascadeREACTOMER-HSA-2514859

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166129466lonafarnibChemicalClinicalAnnotationassociatedPD26033044
PA445204Ovarian NeoplasmsDiseaseClinicalAnnotationassociatedPD26033044
PA448803carboplatinChemicalClinicalAnnotationassociatedPD26033044
PA450761paclitaxelChemicalClinicalAnnotationassociatedPD26033044

References

Pubmed IDYearTitleCitations
117513962001Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.55
229927472012Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways.7
198418752010Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.2
228829152012Expression of farnesyltransferase in primary liver cancer.0
236439862013Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells.0

Citation

Dessen P

FNTB (farnesyltransferase, CAAX box, beta)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53141/fntb