FUT2 (fucosyltransferase 2)

2007-02-01  

Identity

HGNC
FUT2
LOCATION
19q13.33
LOCUSID
2524
ALIAS
B12QTL1,SE,SEC2,Se2,sej
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2524
MIM: 182100
HGNC: 4013
Ensembl: ENSG00000176920

Variants:

dbSNP: 2524
ClinVar: 2524
TCGA: ENSG00000176920
COSMIC: FUT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176920ENST00000391876Q10981
ENSG00000176920ENST00000391876A8K2L2
ENSG00000176920ENST00000425340Q10981
ENSG00000176920ENST00000425340A8K2L2
ENSG00000176920ENST00000522966Q10981
ENSG00000176920ENST00000522966A8K2L2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Glycosphingolipid biosynthesis - globo and isoglobo seriesKEGGhsa00603
Metabolic pathwaysKEGGhsa01100

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD32451486
PA448073ethanolChemicalClinicalAnnotationassociatedPD32451486

References

Pubmed IDYearTitleCitations
205709662010Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.130
205709662010Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.130
220689122011Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype.111
193030622009Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.86
216255102011Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine.85
194873332009A natural history of FUT2 polymorphism in humans.69
194403602009The G428A nonsense mutation in FUT2 provides strong but not absolute protection against symptomatic GII.4 Norovirus infection.64
187769112008Common variants of FUT2 are associated with plasma vitamin B12 levels.59
189970042009Widespread balancing selection and pathogen-driven selection at blood group antigen genes.54
225213422012Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.53

Citation

Dessen P

FUT2 (fucosyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45946/fut2