GREM1 (gremlin 1, DAN family BMP antagonist)

2007-02-01  

Identity

HGNC
LOCATION
15q13.3
LOCUSID
ALIAS
C15DUPq,CKTSF1B1,CRAC1,CRCS4,DAND2,DRM,DUP15q,GREMLIN,HMPS,HMPS1,IHG-2,MPSH,PIG2
FUSION GENES

Other Information

Locus ID:

NCBI: 26585
MIM: 603054
HGNC: 2001
Ensembl: ENSG00000166923

Variants:

dbSNP: 26585
ClinVar: 26585
TCGA: ENSG00000166923
COSMIC: GREM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166923ENST00000560677H0YLY2
ENSG00000166923ENST00000560830O60565
ENSG00000166923ENST00000651154O60565
ENSG00000166923ENST00000651154A6XAA7
ENSG00000166923ENST00000652365O60565
ENSG00000166923ENST00000652365A6XAA7

Expression (GTEx)

0
50
100
150
200
250

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180842922008Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.137
180842922008Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.137
216550892011Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.111
170031132006Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.105
254197072015Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.68
155395602005Skeletal overexpression of gremlin impairs bone formation and causes osteopenia.59
179751992008Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis.57
206602912010Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2.57
245503942014Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.54
179807142008Co-regulation of Gremlin and Notch signalling in diabetic nephropathy.47

Citation

Dessen P

GREM1 (gremlin 1, DAN family BMP antagonist)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43901/grem1