GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A)

2016-01-01 Affiliation

Identity

HGNC

GRIN3A

LOCATION

9q31.1

LOCUSID

116443

ALIAS

GluN3A,NMDAR-L,NMDAR3A,NR3A

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 116443
MIM: 606650
HGNC: 16767
Ensembl: ENSG00000198785

Variants:

dbSNP: 116443
ClinVar: 116443
TCGA: ENSG00000198785
COSMIC: GRIN3A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198785	ENST00000361820	Q8TCU5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Nicotine addiction	KEGG	hsa05033
Nicotine addiction	KEGG	ko05033
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA445876	Tobacco Use Disorder	Disease	ClinicalAnnotation	associated			20084518
PA450626	nicotine	Chemical	ClinicalAnnotation	associated			20084518

References

Pubmed ID	Year	Title	Citations
19488045	2010	Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients.	115
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
19156168	2009	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	46
19386922	2009	Neuroprotection by the NR3A subunit of the NMDA receptor.	45
21152063	2010	Characterisation of the expression of NMDA receptors in human astrocytes.	44
18296432	2008	Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex.	39
23852340	2013	Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.	35
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
26265699	2015	Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia.	34

Citation

Dessen P

GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55598/grin3a