GRK3 (G protein-coupled receptor kinase 3)

2006-10-01 Affiliation

Identity

HGNC

GRK3

LOCATION

22q12.1

LOCUSID

157

ALIAS

ADRBK2,BARK2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 157
MIM: 109636
HGNC: 290
Ensembl: ENSG00000100077

Variants:

dbSNP: 157
ClinVar: 157
TCGA: ENSG00000100077
COSMIC: GRK3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100077	ENST00000324198	P35626
ENSG00000100077	ENST00000324198	A0A024R1D8
ENSG00000100077	ENST00000455558	H7C099
ENSG00000100077	ENST00000619906	Q8N433

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hedgehog signaling pathway	KEGG	ko04340
Olfactory transduction	KEGG	ko04740
Hedgehog signaling pathway	KEGG	hsa04340
Olfactory transduction	KEGG	hsa04740
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA30616	MAPK1	Gene	Pathway	associated
PA39	ADRB2	Gene	Pathway	associated
PA62	ATP1A1	Gene	Pathway	associated	23788015

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
18274673	2008	Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling.	54
20734064	2010	A large-scale candidate gene association study of age at menarche and age at natural menopause.	38
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
20398908	2010	Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.	32
15498832	2005	Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization.	31
20468064	2010	Association study of 182 candidate genes in anorexia nervosa.	30
15728711	2005	ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor.	26
22086906	2012	Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth.	19

Citation

Dessen P

GRK3 (G protein-coupled receptor kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43107/grk3