GSAP (gamma-secretase activating protein)

2014-11-01  

Identity

HGNC
GSAP
LOCATION
7q11.23
LOCUSID
54103
ALIAS
PION
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54103
MIM: 613552
HGNC: 28042
Ensembl: ENSG00000186088

Variants:

dbSNP: 54103
ClinVar: 54103
TCGA: ENSG00000186088
COSMIC: GSAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186088ENST00000257626A4D1B5
ENSG00000186088ENST00000415112H7C0Q7
ENSG00000186088ENST00000430584C9JRG7
ENSG00000186088ENST00000441833B7ZL33

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
208114582010Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.86
232092902013The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.10
217183432012Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.9
250372852014Common GSAP promoter variant contributes to Alzheimer's disease liability.7
226810442012Purification and characterization of the human γ-secretase activating protein.6
260769912015Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence.6
287431262017Frontal Cortex and Hippocampal γ-Secretase Activating Protein Levels in Prodromal Alzheimer Disease.1

Citation

Dessen P

GSAP (gamma-secretase activating protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64070/gsap