H3-3B (H3.3 histone B)

2019-08-01 Affiliation

Identity

HGNC

H3-3B

LOCATION

17q25.1

LOCUSID

3021

ALIAS

H3-3A,H3.3B,H3F3B

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3021
MIM: 601058
HGNC: 4765
Ensembl: ENSG00000132475

Variants:

dbSNP: 3021
ClinVar: 3021
TCGA: ENSG00000132475
COSMIC: H3-3B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000132475	ENST00000254810	P84243
ENSG00000132475	ENST00000254810	B2R4P9
ENSG00000132475	ENST00000586270	K7EK07
ENSG00000132475	ENST00000586607	P84243
ENSG00000132475	ENST00000586607	B2R4P9
ENSG00000132475	ENST00000587171	K7ES00
ENSG00000132475	ENST00000587560	P84243
ENSG00000132475	ENST00000587560	B2R4P9
ENSG00000132475	ENST00000589599	P84243
ENSG00000132475	ENST00000589599	B2R4P9
ENSG00000132475	ENST00000591890	K7EMV3
ENSG00000132475	ENST00000592643	K7EP01

Pathways

Pathway	Source	External ID
Systemic lupus erythematosus	KEGG	ko05322
Systemic lupus erythematosus	KEGG	hsa05322
Transcriptional misregulation in cancer	KEGG	ko05202
Transcriptional misregulation in cancer	KEGG	hsa05202
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Metabolism of proteins	REACTOME	R-HSA-392499
Amyloid fiber formation	REACTOME	R-HSA-977225
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases activate PKNs	REACTOME	R-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	REACTOME	R-HSA-5625886
Signaling by Wnt	REACTOME	R-HSA-195721
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Formation of the beta-catenin:TCF transactivating complex	REACTOME	R-HSA-201722
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	REACTOME	R-HSA-504046
RNA Polymerase I Transcription	REACTOME	R-HSA-73864
RNA Polymerase I Promoter Clearance	REACTOME	R-HSA-73854
RNA Polymerase I Promoter Opening	REACTOME	R-HSA-73728
RNA Polymerase I Chain Elongation	REACTOME	R-HSA-73777
Gene Silencing by RNA	REACTOME	R-HSA-211000
Transcriptional regulation by small RNAs	REACTOME	R-HSA-5578749
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
PRC2 methylates histones and DNA	REACTOME	R-HSA-212300
Negative epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250941
SIRT1 negatively regulates rRNA Expression	REACTOME	R-HSA-427359
NoRC negatively regulates rRNA expression	REACTOME	R-HSA-427413
DNA methylation	REACTOME	R-HSA-5334118
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Condensation of Prophase Chromosomes	REACTOME	R-HSA-2299718
Meiosis	REACTOME	R-HSA-1500620
Meiotic recombination	REACTOME	R-HSA-912446
Developmental Biology	REACTOME	R-HSA-1266738
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP)	REACTOME	R-HSA-2559582
Positive epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250913
B-WICH complex positively regulates rRNA expression	REACTOME	R-HSA-5250924
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	REACTOME	R-HSA-427389

References

Pubmed ID	Year	Title	Citations
20504901	2010	The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.	271
24162739	2013	Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.	152
26457357	2015	Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma.	25
28882701	2017	Diagnostic value of histone 3 mutations in osteoclast-rich bone tumors.	2
29529098	2018	Validation of a microRNA target site polymorphism in H3F3B that is potentially associated with a broad schizophrenia phenotype.	2
28129023	2017	Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells.	1
29894858	2018	Putative functional SNPs in SLC22A3 and H3F3B might influence the development of CAD by regulating the lipid levels.	0

Citation

Dessen P

H3-3B (H3.3 histone B)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58123/h3-3b