HCAR1 (hydroxycarboxylic acid receptor 1)

2015-02-01 Affiliation

Identity

HGNC

HCAR1

LOCATION

12q24.31

LOCUSID

27198

ALIAS

FKSG80,GPR104,GPR81,HCA1,LACR1,TA-GPCR,TAGPCR

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 27198
MIM: 606923
HGNC: 4532
Ensembl: ENSG00000196917

Variants:

dbSNP: 27198
ClinVar: 27198
TCGA: ENSG00000196917
COSMIC: HCAR1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000196917	ENST00000432564	Q9BXC0
ENSG00000196917	ENST00000432564	A0A4Y1JWP1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Hydroxycarboxylic acid-binding receptors	REACTOME	R-HSA-3296197
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
24657625	2014	Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity.	76
18952058	2008	Role of GPR81 in lactate-mediated reduction of adipose lipolysis.	52
24928781	2014	Cell surface lactate receptor GPR81 is crucial for cancer cell survival.	40
28604752	2017	Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells.	40
26208712	2015	L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation.	23
19633298	2009	Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81).	19
25839160	2015	Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism.	14
27765922	2016	G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion.	14
21862690	2011	Study of GPR81, the lactate receptor, from distant species identifies residues and motifs critical for GPR81 functions.	13

Citation

Dessen P

HCAR1 (hydroxycarboxylic acid receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54981/hcar1