HCAR3 (hydroxycarboxylic acid receptor 3)

2011-10-01  

Identity

HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
GPR109B,HCA3,HM74,PUMAG,Puma-g

Other Information

Locus ID:

NCBI: 8843
MIM: 606039
HGNC: 16824
Ensembl: ENSG00000255398

Variants:

dbSNP: 8843
ClinVar: 8843
TCGA: ENSG00000255398
COSMIC: HCAR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000255398ENST00000528880P49019

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hydroxycarboxylic acid-binding receptorsREACTOMER-HSA-3296197
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125633152003PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.164
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
195610682009Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis.24
192375842009Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B.19
196332982009Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81).19
195020102009Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.14
195020102009Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.14
258391602015Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism.14
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
222891632012Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways.9

Citation

Dessen P

HCAR3 (hydroxycarboxylic acid receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52451/hcar3