HDLBP (high density lipoprotein binding protein)

2007-04-01  

Identity

HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
HBP,PRO2900,VGL
FUSION GENES

Other Information

Locus ID:

NCBI: 3069
MIM: 142695
HGNC: 4857
Ensembl: ENSG00000115677

Variants:

dbSNP: 3069
ClinVar: 3069
TCGA: ENSG00000115677
COSMIC: HDLBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115677ENST00000310931A0A024R4E5
ENSG00000115677ENST00000373292H0Y394
ENSG00000115677ENST00000391975A0A024R4E5
ENSG00000115677ENST00000391976A0A024R4E5
ENSG00000115677ENST00000413241C9JHN6
ENSG00000115677ENST00000417540C9JB08
ENSG00000115677ENST00000420451C9JBS3
ENSG00000115677ENST00000422080C9JQ82
ENSG00000115677ENST00000422933C9JIZ1
ENSG00000115677ENST00000423693C9JHN6
ENSG00000115677ENST00000425989C9JEJ8
ENSG00000115677ENST00000426343C9JT62
ENSG00000115677ENST00000427007C9J739
ENSG00000115677ENST00000427183Q00341
ENSG00000115677ENST00000427487H7C2D1
ENSG00000115677ENST00000428482C9J5E5
ENSG00000115677ENST00000430918C9JHZ8
ENSG00000115677ENST00000441124C9JHS7
ENSG00000115677ENST00000442714C9JK79
ENSG00000115677ENST00000442730H7C3D0
ENSG00000115677ENST00000444092C9JES8
ENSG00000115677ENST00000449504C9JHS9
ENSG00000115677ENST00000449864C9JE93
ENSG00000115677ENST00000452065C9JZI8
ENSG00000115677ENST00000452931H7BZC3
ENSG00000115677ENST00000453141H7C0A4
ENSG00000115677ENST00000458564C9JMQ6

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
HDL-mediated lipid transportREACTOMER-HSA-194223

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
198785692009Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.28
186480732008On the mechanism of induction of heterochromatin by the RNA-binding protein vigilin.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
209748092011Posttranscriptional suppression of proto-oncogene c-fms expression by vigilin in breast cancer.10
204427502010Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study.6
246764542014Vigilin is overexpressed in hepatocellular carcinoma and is required for HCC cell proliferation and tumor growth.6
145008282003RNAi-mediated depletion of the 15 KH domain protein, vigilin, induces death of dividing and non-dividing human cells but does not initially inhibit protein synthesis.5
151095742004Vigilin is co-localized with 80S ribosomes and binds to the ribosomal complex through its C-terminal domain.5
289757342017A jack of all trades: the RNA-binding protein vigilin.5

Citation

Dessen P

HDLBP (high density lipoprotein binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47432/hdlbp