HMG20B (high mobility group 20B)

2003-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
BRAF25,BRAF35,HMGX2,HMGXB2,PP7706,SMARCE1r,SOXL,pp8857
FUSION GENES

Other Information

Locus ID:

NCBI: 10362
MIM: 605535
HGNC: 5002
Ensembl: ENSG00000064961

Variants:

dbSNP: 10362
ClinVar: 10362
TCGA: ENSG00000064961
COSMIC: HMG20B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064961ENST00000262949B5MDG7
ENSG00000064961ENST00000333651Q9P0W2
ENSG00000064961ENST00000416526C9J8X5
ENSG00000064961ENST00000417382C9K049
ENSG00000064961ENST00000435022F8WES5
ENSG00000064961ENST00000453933C9JQA7
ENSG00000064961ENST00000585900K7EJR8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
120322982002A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.114
225705002012Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex.23
179611342007Expression of SoxE and SoxD genes in human gliomas.17
213996662011A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.11
205304872010The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.10
128095542003Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35.8
287606572017The E3 ubiquitin ligase MID1/TRIM18 promotes atypical ubiquitination of the BRCA2-associated factor 35, BRAF35.3
119970922002Characterization of human SMARCE1r high-mobility-group protein.2
254861962014A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis.1
120837792002Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35.0

Citation

Dessen P

HMG20B (high mobility group 20B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40833/hmg20b