HMOX1 (heme oxygenase 1)

2003-08-01  

Identity

HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
HMOX1D,HO-1,HSP32,bK286B10
FUSION GENES

Other Information

Locus ID:

NCBI: 3162
MIM: 141250
HGNC: 5013
Ensembl: ENSG00000100292

Variants:

dbSNP: 3162
ClinVar: 3162
TCGA: ENSG00000100292
COSMIC: HMOX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100292ENST00000216117P09601
ENSG00000100292ENST00000216117Q6FH11
ENSG00000100292ENST00000412893B1AHA8

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Porphyrin and chlorophyll metabolismKEGGko00860
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolic pathwaysKEGGhsa01100
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
HIF-1 signaling pathwayKEGGhsa04066
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
MetabolismREACTOMER-HSA-1430728
Metabolism of porphyrinsREACTOMER-HSA-189445
Heme degradationREACTOMER-HSA-189483
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121304982002Pro-oxidant and cytotoxic effects of circulating heme.149
172299062007Physiology and pathophysiology of heme: implications for kidney disease.110
150041562004Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation.104
154510512004The role of heme oxygenase-1 promoter polymorphisms in human disease.104
214545552011Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression.104
164850412006Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice.101
194459072009Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia.94
129417742003Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism.93
120912402002Heme oxygenase-1: the "emerging molecule" has arrived.92
121362292002Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients.91

Citation

Dessen P

HMOX1 (heme oxygenase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40838/hmox1