HMOX2 (heme oxygenase 2)

2003-08-01  

Identity

HGNC
HMOX2
LOCATION
16p13.3
LOCUSID
3163
ALIAS
HO-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3163
MIM: 141251
HGNC: 5014
Ensembl: ENSG00000103415

Variants:

dbSNP: 3163
ClinVar: 3163
TCGA: ENSG00000103415
COSMIC: HMOX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103415ENST00000219700P30519
ENSG00000103415ENST00000398595P30519
ENSG00000103415ENST00000406590P30519
ENSG00000103415ENST00000414777P30519
ENSG00000103415ENST00000458134P30519
ENSG00000103415ENST00000570445I3L159
ENSG00000103415ENST00000570622I3L1Y2
ENSG00000103415ENST00000570646P30519
ENSG00000103415ENST00000572812I3L276
ENSG00000103415ENST00000574466I3L4P8
ENSG00000103415ENST00000575051I3L1F5
ENSG00000103415ENST00000575120P30519
ENSG00000103415ENST00000575129I3L463
ENSG00000103415ENST00000576827A0A1B0GXH0
ENSG00000103415ENST00000613539A0A087WT44
ENSG00000103415ENST00000619528P30519
ENSG00000103415ENST00000619913P30519

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Porphyrin and chlorophyll metabolismKEGGko00860
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolic pathwaysKEGGhsa01100
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
MetabolismREACTOMER-HSA-1430728
Metabolism of porphyrinsREACTOMER-HSA-189445
Heme degradationREACTOMER-HSA-189483
Neutrophil degranulationREACTOMER-HSA-6798695
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
155284062004Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel.130
175407722007Evidence that the heme regulatory motifs in heme oxygenase-2 serve as a thiol/disulfide redox switch regulating heme binding.41
194739662009Heme regulatory motifs in heme oxygenase-2 form a thiol/disulfide redox switch that responds to the cellular redox state.37
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
179650152007Comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2.24
145069302003Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies.23
189772412008Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.20
193998162009Cellular mRNA expressions of anti-oxidant factors in the blood of preeclamptic women.17
201182442010Enhanced translation of heme oxygenase-2 preserves human endothelial cell viability during hypoxia.16
251968432014Protein/protein interactions in the mammalian heme degradation pathway: heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase.16

Citation

Dessen P

HMOX2 (heme oxygenase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40839/hmox2