HOOK3 (hook microtubule tethering protein 3)

2012-11-01  

Identity

HGNC
HOOK3
LOCATION
8p11.21
LOCUSID
84376
ALIAS
HK3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84376
MIM: 607825
HGNC: 23576
Ensembl: ENSG00000168172

Variants:

dbSNP: 84376
ClinVar: 84376
TCGA: ENSG00000168172
COSMIC: HOOK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168172ENST00000307602Q86VS8
ENSG00000168172ENST00000526882H0YE69
ENSG00000168172ENST00000533338H0YDK4
ENSG00000168172ENST00000533539H0YDM4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
274820522016Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.47
201521262010Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis.44
273654012016Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.37
129509212003The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking.19
176390572007HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma.13
172372312007The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A.11
257994092015Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.6
312174192019PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.4
262308422015High-Level HOOK3 Expression Is an Independent Predictor of Poor Prognosis Associated with Genomic Instability in Prostate Cancer.3

Citation

Dessen P

HOOK3 (hook microtubule tethering protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53008/hook3