HOXD10 (homeobox D10)

2011-09-01  

Identity

HGNC
HOXD10
LOCATION
2q31.1
LOCUSID
3236
ALIAS
HOX4,HOX4D,HOX4E,Hox-4.4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3236
MIM: 142984
HGNC: 5133
Ensembl: ENSG00000128710

Variants:

dbSNP: 3236
ClinVar: 3236
TCGA: ENSG00000128710
COSMIC: HOXD10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128710ENST00000249501P28358

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
189228902008MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions.112
243766402013MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration.81
214191072011MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10.75
222936822012miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancer.56
124661262002Sustained expression of homeobox D10 inhibits angiogenesis.46
245733542014MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer.46
236705322013Loss of HOXD10 expression induced by upregulation of miR-10b accelerates the migration and invasion activities of ovarian cancer cells.39
242190322014miR-224 promotion of cell migration and invasion by targeting Homeobox D 10 gene in human hepatocellular carcinoma.35
221603932012Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis.26
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20

Citation

Dessen P

HOXD10 (homeobox D10)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/52373/hoxd10