IBTK (inhibitor of Bruton tyrosine kinase)

2014-08-01  

Identity

HGNC
LOCATION
6q14.1
LOCUSID
ALIAS
BTBD26,BTKI
FUSION GENES

Other Information

Locus ID:

NCBI: 25998
MIM: 606457
HGNC: 17853
Ensembl: ENSG00000005700

Variants:

dbSNP: 25998
ClinVar: 25998
TCGA: ENSG00000005700
COSMIC: IBTK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005700ENST00000306270Q9P2D0
ENSG00000005700ENST00000471036H0Y9N7
ENSG00000005700ENST00000503400D6R9F4
ENSG00000005700ENST00000503631E9PDR5
ENSG00000005700ENST00000510291E7EPI0
ENSG00000005700ENST00000610980E9PDR5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
246484952014Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα.44
185960812008Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk.17
214827052011Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ.11
258828422015CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation.11
197820032009Computational analysis and in vivo validation of a microRNA encoded by the IBTK gene, a regulator of B-lymphocytes differentiation and survival.8
287102822017Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.6
278279942016IBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells.4
293176362018The expression of inhibitor of bruton's tyrosine kinase gene is progressively up regulated in the clinical course of chronic lymphocytic leukaemia conferring resistance to apoptosis.4
207214702010Mutations of Bruton's tyrosine kinase gene in Brazilian patients with X-linked agammaglobulinemia.1

Citation

Dessen P

IBTK (inhibitor of Bruton tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54371/ibtk