IFI27 (interferon alpha inducible protein 27)

2007-02-01  

Identity

HGNC
IFI27
LOCATION
14q32.12
LOCUSID
3429
ALIAS
FAM14D,ISG12,ISG12A,P27
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3429
MIM: 600009
HGNC: 5397
Ensembl: ENSG00000165949

Variants:

dbSNP: 3429
ClinVar: 3429
TCGA: ENSG00000165949
COSMIC: IFI27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165949ENST00000555819G3V4U3
ENSG00000165949ENST00000612813P40305
ENSG00000165949ENST00000614204A0A087WV79
ENSG00000165949ENST00000614288A0A087X035
ENSG00000165949ENST00000616764P40305
ENSG00000165949ENST00000618200A0A087WUJ8
ENSG00000165949ENST00000618863P40305
ENSG00000165949ENST00000620066A0A087WZR1
ENSG00000165949ENST00000620396A0A087X174
ENSG00000165949ENST00000621160P40305

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
183307072008Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a.39
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
214470072011Whole-blood transcriptional profiling of interferon-inducible genes identifies highly upregulated IFI27 in primary myelofibrosis.22
251036402015Interferon alpha-inducible protein 27 promotes epithelial-mesenchymal transition and induces ovarian tumorigenicity and stemness.19
171662822006Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis.17
249708062014miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT.17
150637622004Genetic variations in humans associated with differences in the course of hepatitis C.16
183614272008Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer.16
195585032009Identification of new sensitive biomarkers for the in vivo response to interferon-beta treatment in multiple sclerosis using DNA-array evaluation.13
224273402012The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors.12

Citation

Dessen P

IFI27 (interferon alpha inducible protein 27)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46294/ifi27