IFI35 (interferon induced protein 35)

2018-07-01  

Identity

HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
IFP35
FUSION GENES

Other Information

Locus ID:

NCBI: 3430
MIM: 600735
HGNC: 5399
Ensembl: ENSG00000068079

Variants:

dbSNP: 3430
ClinVar: 3430
TCGA: ENSG00000068079
COSMIC: IFI35

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000068079ENST00000415816P80217
ENSG00000068079ENST00000438323P80217

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
243710602014Interferon-inducible protein IFI35 negatively regulates RIG-I antiviral signaling and supports vesicular stomatitis virus replication.26
183050402008IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus.24
171971582007The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling.18
263424642015Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response.9
250856222014A critical role of interferon-induced protein IFP35 in the type I interferon response in cells induced by foot-and-mouth disease virus (FMDV) protein 2C.7
119118072002Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells.5
290384652017NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.5
232265492012Interferon-γ upregulates expression of IFP35 gene in HeLa cells via interferon regulatory factor-1.4
276396182016Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.4

Citation

Dessen P

IFI35 (interferon induced protein 35)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57542/ifi35